Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61
![The role of hedgehog signaling in gastric cancer: molecular mechanisms, clinical potential, and perspective. - Abstract - Europe PMC The role of hedgehog signaling in gastric cancer: molecular mechanisms, clinical potential, and perspective. - Abstract - Europe PMC](https://europepmc.org/articles/PMC6882007/bin/12964_2019_479_Fig3_HTML.jpg)
The role of hedgehog signaling in gastric cancer: molecular mechanisms, clinical potential, and perspective. - Abstract - Europe PMC
![GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment | Journal of Experimental & Clinical Cancer Research | Full Text GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment | Journal of Experimental & Clinical Cancer Research | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13046-016-0463-3/MediaObjects/13046_2016_463_Fig2_HTML.gif)
GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment | Journal of Experimental & Clinical Cancer Research | Full Text
![Effect of the combination of metformin and GANT61 on radiosensitivity... | Download Scientific Diagram Effect of the combination of metformin and GANT61 on radiosensitivity... | Download Scientific Diagram](https://www.researchgate.net/profile/Chad_Mckee/publication/315924176/figure/fig4/AS:481978026860549@1491923924803/Effect-of-the-combination-of-metformin-and-GANT61-on-radiosensitivity-in-a-22Rv1_Q640.jpg)
Effect of the combination of metformin and GANT61 on radiosensitivity... | Download Scientific Diagram
![Schematic overview of different GANT61 target sites. Inhibition of the... | Download Scientific Diagram Schematic overview of different GANT61 target sites. Inhibition of the... | Download Scientific Diagram](https://www.researchgate.net/profile/Annelies_Gonnissen/publication/277958538/figure/fig2/AS:294420114100265@1447206633948/Schematic-overview-of-different-GANT61-target-sites-Inhibition-of-the-GLI-transcription.png)
Schematic overview of different GANT61 target sites. Inhibition of the... | Download Scientific Diagram
![GANT-61 treatment to RMS cells inhibits proliferation, colony formation... | Download Scientific Diagram GANT-61 treatment to RMS cells inhibits proliferation, colony formation... | Download Scientific Diagram](https://www.researchgate.net/profile/Changzhao_Li/publication/269038807/figure/fig3/AS:295413031686145@1447443363323/GANT-61-treatment-to-RMS-cells-inhibits-proliferation-colony-formation-and-induces-cell.png)
GANT-61 treatment to RMS cells inhibits proliferation, colony formation... | Download Scientific Diagram
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61
![GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment | Journal of Experimental & Clinical Cancer Research | Full Text GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment | Journal of Experimental & Clinical Cancer Research | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13046-016-0463-3/MediaObjects/13046_2016_463_Fig3_HTML.gif)
GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment | Journal of Experimental & Clinical Cancer Research | Full Text
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61
![Frontiers | The Combination of Particle Irradiation With the Hedgehog Inhibitor GANT61 Differently Modulates the Radiosensitivity and Migration of Cancer Cells Compared to X-Ray Irradiation | Oncology Frontiers | The Combination of Particle Irradiation With the Hedgehog Inhibitor GANT61 Differently Modulates the Radiosensitivity and Migration of Cancer Cells Compared to X-Ray Irradiation | Oncology](https://www.frontiersin.org/files/Articles/435530/fonc-09-00391-HTML/image_m/fonc-09-00391-g003.jpg)
Frontiers | The Combination of Particle Irradiation With the Hedgehog Inhibitor GANT61 Differently Modulates the Radiosensitivity and Migration of Cancer Cells Compared to X-Ray Irradiation | Oncology
![RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism - ScienceDirect RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0304383518306682-gr5.jpg)
RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism - ScienceDirect
![Effect of GANT61 and IR in vivo. (A) Relative tumor growth of 22Rv1... | Download Scientific Diagram Effect of GANT61 and IR in vivo. (A) Relative tumor growth of 22Rv1... | Download Scientific Diagram](https://www.researchgate.net/profile/Chad_Mckee/publication/315925075/figure/fig6/AS:481981197754375@1491924680902/Effect-of-GANT61-and-IR-in-vivo-A-Relative-tumor-growth-of-22Rv1-left-and-PC3.png)
Effect of GANT61 and IR in vivo. (A) Relative tumor growth of 22Rv1... | Download Scientific Diagram
![Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer | Open Biology Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer | Open Biology](https://royalsocietypublishing.org/cms/asset/83659a56-a316-43ee-8e3b-37e73ae8ce97/rsob180098f02.jpg)
Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer | Open Biology
![Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo - Wickström - 2013 - International Journal of Cancer - Wiley Online Library Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo - Wickström - 2013 - International Journal of Cancer - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/dfcbe7e6-001f-48e4-8320-845455d994b7/mfig003.jpg)
Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo - Wickström - 2013 - International Journal of Cancer - Wiley Online Library
Blocking Signaling at the Level of GLI Regulates Downstream Gene Expression and Inhibits Proliferation of Canine Osteosarcoma Cells
![Cells | Free Full-Text | Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer | HTML Cells | Free Full-Text | Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer | HTML](https://www.mdpi.com/cells/cells-08-00394/article_deploy/html/images/cells-08-00394-g001.png)